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Sudden appearance, or rapid increase in size and number, of seborrheic keratoses or freckles
    Differential Diagnosis[Top] [Nav]
internal malignancy
    Discussion -- not available online[Top] [Nav]
    Footnotes in Print Edition[Top] [Nav]
    (1) The sign of Leser-Trelat. A cutaneous marker for internal malignancy.
  Halevy S, Feuerman EJ.   Int J Dermatol 1985 Jul-Aug;24(6):359-61.  Pubmed  Similars
    (2) [This footnote was a comment, not a reference.]
    (3) Florid cutaneous papillomatosis.
  Schwartz RA, Burgess GH.   Arch Dermatol 1978 Dec;114(12):1803-6.  Pubmed+Abstract  Similars
    (4) Melanoma, growth factors, acanthosis nigricans, the sign of Leser- Trelat, and multiple acrochordons. A possible role for alpha- transforming growth factor in cutaneous paraneoplastic syndromes.
  Ellis DL, Kafka SP, et al.   N Engl J Med 1987 Dec 17;317(25):1582-7.  Pubmed  Similars
    (5) Evaluation of acromegaly by radioimmunoassay of somatomedin-C.
  Clemmons DR, Van Wyk JJ, et al.   N Engl J Med 1979 Nov 22;301(21):1138-42.  Pubmed+Abstract  Similars
    (-) Skin signs of internal malignancy.
  Callen JP (ed).   Semin Dermatol. 1984;3:265-357.
This single-theme issue is, unfortunately, not indexed by Medline. It contains the 10 articles whose citations follow:
  • Andreev VC. Malignant acanthosis nigricans. Semin Dermatol 1984;3:265-272.
  • Gentry WC Jr. Autosomal dominant genodermatoses associate with internal malignant disease. Semin Dermatol 1984;3:273-281.
  • Kassis V, Sondergaard J. Hypertrichosis lanuginosa. Semin Dermatol 1984;3:282-286.
  • Verbov J, Belchetz PE. Cutaneous syndromes due to hormones produced by tumors. Semin Dermatol 1984;3:287-294.
  • Tuffanelli DL. Collagen vascular disease and cancer. Semin Dermatol 1984;3:295-302.
  • Schwartz RA, et al. Kaposi's sarcoma. Semin Dermatol 1984;3:303-315.
  • Jablonski S, et al. Bullous diseases and malignancy. Semin Dermatol 1984;3:316-326.
  • Hurley HJ, Hurley JP. The gyrate erythemas. Semin Dermatol 1984;3:327-336.
  • Soderstrom RM. Acute febrile neutrophilic dermatosis (Sweet's syndrome) and internal malignancy. Semin Dermatol 1984;3:337-339.
  • Callen JP. Skin signs of internal malignancy: fact, fancy, and fiction. Semin Dermatol 1984;3:340-357.
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    ©1986-2000 John Sotos, MD. All rights reserved.  Last updated 16:33 PDT on July 4, 2000.[Top]

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